Piperazine from worms instruction. How to use piperazine for parasites. Piperazine during pregnancy and lactation

Piperazine adipinate is the basis of the anthelminthic drug Piperazine, which is most commonly used to treat pinworms in adult patients. The use of the drug is as simple as possible due to the tablet form of release.

Piperazine adipinate is most commonly used for the treatment of enterobiasis and ascariasis. The drug is widely used to treat pinworms in adults. These tablets from worms are characterized by a paralyzing effect on nematodes. Piperazine adipate is capable of disrupting the functioning of the neuromuscular system of helminthic invasions, which leads to paralysis of the muscles and their death.

The removal of worms during the period of use of the drug is carried out in 95 percent of cases. The likelihood of recurrence of helminthic invasions is very small. If Piperazine adipate is used for a second course of treatment, then this leads to the complete elimination of helminthic invasions. Piperazine tablets are not able to destroy ascaris.

Indications and contraindications

Instructions for use of piperazine adipinate contain more detailed information, according to which the drug has a minimum number of contraindications, which allows the use of the drug for the treatment of a wide range of patients.

Contraindication to use is hypersensitivity to components. Do not use the medicine in the presence of diseases of the central nervous system, which are of an organic nature. If the patient has chronic renal failure, then treatment with the drug is prohibited.

If a doctor prescribes a drug to a patient, then the doctor must take into account that he is increasing the side effects of chlorpromazine.

Application of the drug

Before taking Piperazine from worms, it is necessary to determine the presence of allergic reactions to its components. The dose of the drug is determined in accordance with the characteristics of the course of the disease.

If the patient has ascariasis, then he needs to take from 0.5 to 2 grams of the drug. With insufficient effectiveness of Piperazine, the instructions for use allow you to increase the amount of the substance up to 3-4 grams, but no more.

Reception of Piperazine to children in the above dosage is allowed only if their age is from 13 to 15 years. At the age of 9 to 12 years, children are recommended to take no more than two grams of the drug. The dosage of piperazine adipinate for patients aged 3 to 5 years should be 0.5 to 1 gram. If children are treated from 2 to 3 years old, then they need to be given from 0.3 to 0.6 grams of the drug. The traditional medication is allowed for the treatment of children up to a year at a dose of 0.2 to 0.4 grams.

The route of administration of the drug is oral. Instructions for using the medicine require drinking it with clean water. Reception should be carried out within two weeks, after which you can take a break. If necessary, the course of treatment is repeated.

Can piperazine treat enterobiasis? When this disease appears, it is recommended to take medicine for people in the same doses as for ascariasis. The duration of therapy should be at least five days.

To completely eliminate pinworms, the patient must undergo 1 to 3 courses of treatment. Between them there should be a break of one week.

Since the drug paralyzes the worms, and not their excretion, it is recommended to regularly put a cleansing enema in order to avoid poisoning with decay toxins. To prepare the solution, boiled water is taken in an amount of 1200 to 1600 milliliters. Add soda to it. For each glass of water, a teaspoon of soda is relied upon.

If the patient has ascariasis, then the enema should be performed after the end of the course of treatment. Therapy of enterobiasis requires an enema in between courses. If the therapy of enterobiasis continues for a sufficiently long time, then this requires strict adherence to the rules of personal hygiene.

Representatives of the weaker sex are recommended to use Piperazine during pregnancy. This is due to the fact that the analogues of the drug are less safe. The use of the drug can be carried out during the period of breastfeeding of newborns. In this case, for women, the dosage of the traditional medication is the same as for adult patients.

Side effects and overdose

If the medication is taken incorrectly or there are contraindications, side effects may occur in patients. In most cases, patients complain of:

• headache;
• nausea;
• vomiting;
• abdominal pain that is spastic in nature.

If the patient has renal failure, then taking a traditional medication can lead to neurotoxic complications. Some patients complain of tremors and muscle weakness.

Taking the drug may be accompanied by euphoria and hallucinations. In a certain group of patients, vision deteriorated during the period of taking the medication. Sometimes the treatment led to the appearance of disorders in the coordination of movements.

With an overdose of the drug, the corresponding symptoms occur. Excessively high doses of the drug lead to muscle weakness and tremors. If an overdose occurs, the patient must necessarily rinse the stomach, it is recommended to drink activated charcoal or other enterosorbents. Doctors in this case prescribe saline laxatives. If necessary, patients are prescribed transfusion therapy. With the development of neurological symptoms, the introduction of thiamine is recommended.

Despite the high efficacy and safety of the drug, the patient is advised to consult a doctor before using Piperazine, which will ensure the effectiveness of the treatment.

Piperazine is an anthelmintic. It has a paralyzing effect on nematodes, disrupting the function of their neuromuscular system.

Organic matter, refers to aliphatic cyclic amines, has a wide range of applications. Piperazine (as well as its salts) are widely used in medicine and veterinary medicine as an anthelmintic agent.

The drug is effective in ascariasis and enterobiasis. It has a paralyzing effect on nematodes: disrupting the function of their neuromuscular system, causes muscle paralysis.

The severity of deworming with the drug is at the level of 90-95%, and with repeated use it can be about 100%. Due to the fact that Piperazine does not destroy ascaris, there is no danger of absorption of biological toxic products of their decay. The drug has low toxicity.

Piperazine is produced in tablets and solution for children. During pregnancy, it is the only anthelmintic drug allowed for women during this period.

Indications for use

What helps piperazine? According to the instructions, the drug is prescribed in the following cases:

• Enterobiasis.
• Ascariasis.

Instructions for use Piperazine, dosage

The drug is taken orally.

Ascariasis

Piperazine for children is used in dosages:

• at the age of up to 1 year - 0.2 g (0.4 g / day);
• from 2 to 3 years - 0.3 g (0.6 g / day);
• from 4 to 5 years - 0.5 g (1 g / day);
• from 6 to 8 years - 0.75 g (1.5 g / day);
• from 9 to 12 years - 1 g (2 g / day);
• from 13 to 15 years - 1.5 g (3 g / day).

In the treatment of ascariasis, Piperazine can be prescribed 2 times a day 1 hour before or 30-60 minutes after meals for 2 consecutive days.

According to another scheme, the drug is prescribed for 1 day: depending on age, it is taken once at a dose of 0.4 g to 4 g or 2 times a day at a dose of 0.2 g to 2 g.

Piperazine with these helminthiases in adults is used according to the same schemes as in children. Doses for adults are: single - 1.5-2 g, daily - 3-4 g.

Enterobiasis

With enterobiasis, the drug is taken in the same doses, but longer - for 5 days. At the same time, to get rid of pinworms, it is necessary to go through 1-3 courses, between which week breaks are made.

Since Piperazine only paralyzes the worms and does not ensure their excretion, in order to avoid poisoning by their decay products, the instructions for use recommend removing helminths from the rectum with a cleansing enema. The enema solution is prepared from 200-600 ml of water and soda. For 100 ml of water, there are 0.25 teaspoons of soda.

With ascariasis, an enema is given after treatment, and with enterobiasis - between courses during each weekly break.

Application for animals

The drug is actively used to treat domestic and farm animals. Instructions for use of Piperazine for animals prescribe to give the drug orally for uncinariasis, toxascariasis, trichuriasis and hookworm infection for 2 days at 100 mg / kg for cats and 200 mg / kg for dogs per day.

special instructions

Deworming does not require a special diet or preparation. A laxative is prescribed only for a tendency to constipation.

During the treatment of enterobiasis, a strict hygienic regimen is observed. Treatment can be carried out on an outpatient basis.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Piperazine:

• Nausea, spastic abdominal pain, headache.
• In persons with renal insufficiency - neurotoxic complications (muscle weakness, tremor, euphoria, hallucinations, blurred vision, impaired coordination of movements).

Contraindications

Piperazine is contraindicated in the following cases:

• With lesions of the central nervous system of an organic nature;
• Chronic renal failure;
• With hypersensitivity.

The drug enhances the side effects of chlorpromazine.

Overdose

Symptoms of an overdose are a lack of coordination, tremor, weakness, abdominal pain of a spastic nature. In individuals with impaired renal function, a number of neurotoxic events may occur.

Gastric lavage with a suspension of enterosorbents, saline laxatives, infusion therapy, oxygen therapy, and symptomatic therapy are recommended. For neurotoxic symptoms, thiamine hydrochloride is used.

In this article, you can read the instructions for using the drug Piperazine. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Piperazine in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Piperazine in the presence of existing structural analogues. Use for the treatment of ascariasis, enterobiasis and other worms in adults, children, as well as during pregnancy and lactation. The composition of the drug.

Piperazine- anthelmintic agent. It has a paralyzing effect on nematodes, disrupting the function of their neuromuscular system.

Compound

Piperazine adipate + excipients.

Indications

• ascariasis;
• enterobiasis.

Release form

Tablets 200 mg and 500 mg Adipate.

Instructions for use and dosage

When ascariasis is taken for 2 days in a row, 2 times a day 1 hour before or 0.5-1 hour after meals in the following doses:

Adults - a single dose of 1.5-2 g.

• 13-15 years - a single dose of 1.5 g;
• 9-12 years - a single dose of 1 g;
• 6-8 years - a single dose of 750 mg;
• 4-5 years - a single dose of 500 mg;
• 2-3 years - a single dose of 300 mg;
• up to 1 year - a single dose of 200 mg.

It is also possible to use within one day: once from 400 mg to 4 g (depending on age) or 2 times from 200 mg to 2 g.

With enterobiasis, they are used in the same doses for 5 days in a row, 1-3 cycles of treatment are carried out with a 7-day break. In between cycles, it is recommended to prescribe an enema at night (to remove pinworms from the rectum): for adults - from 4-5 glasses of water, for children - from 1-3 glasses of water (with the addition of sodium bicarbonate, 1/2 teaspoon per glass of water) .

Side effect

• nausea;
• stomach ache;
• transient headache;
• neurotoxic complications;
• tremor;
• muscle weakness.

Contraindications

• organic diseases of the central nervous system;
• hypersensitivity to piperazine adipate.

Use during pregnancy and lactation

Not contraindicated in pregnancy and breastfeeding.

Use in children

It is possible to use the drug in children at the age dosages indicated above.

special instructions

The use of piperazine does not require preliminary preparation of patients and the appointment of a special diet. Laxatives are prescribed only with a tendency to constipation (on the days of taking piperazine in the evening). In the treatment of enterobiasis, strict adherence to the hygienic regimen is necessary.

drug interaction

With the combined use of piperazine, it increases the severity of extrapyramidal disorders caused by chlorpromazine.

Simultaneous use with pyrantel is not recommended.

Analogues of the drug Piperazine

Structural analogues for the active substance:

• Piperazine adipate.

Analogues for the therapeutic effect (antihelminthics):

• Biltricide;
• Vermox;
• Wormin;
• Gelmodol VM;
• Helmintox;
• Decaris;
• mebendazole;
• Medamin;
• Nemozol;
• Nemocide;
• Pirantel;
• Pyrantel pamoate;
• Pirvinium;
• Sanoxal;
• Telmox 100.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

One tablet of Piperazine Adipate contains 500 mg piperazine adipate .

Additional components: starch, calcium stearate.

Release form

Flat-cylindrical white tablets with a serif on one side.

• 10 tablets of Piperazine adipate in a blister pack, one pack in a cardboard box.
• 10 tablets of Piperazine adipate in a cell-free package, one package in a carton box.

pharmachologic effect

Antihelminthic action.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Means for therapy enterobiasis And . It affects ascaris and pinworms, both immature and sexually mature, of all sexes, paralyzing the muscles of nematodes, disrupting the system of their neuromuscular transmission.

The effectiveness of deworming is 90-95% with a single dose of the product, and with repeated use it reaches 100%. As a result of the fact that the drug does not affect the shell of ascaris, but causes paralysis of their muscles, there is no dangerous possibility of absorption of toxic biological decay products of helminths. When infected with other nematodes, as well as with trematodes and cestodosis, the remedy is ineffective.

Pharmacokinetics

Rapidly absorbed from the digestive tract. It is excreted by the kidneys.

Indications for use

• Enterobiasis.

Contraindications

The drug is contraindicated in the presence of any of its components, jade , with organic lesions of the central nervous system, hepatic or chronic type.

Side effects

• allergic reactions: skin rashes (including erythema multiforme, purpura ), bronchospasm, Steven-Johnson syndrome, arthralgia.
• Reactions from the nervous system: ataxia , dizziness, headache, drowsiness, weakness, euphoria, hallucinations , blurred vision, nystagmus , lack of coordination, , areflexia, chorea, seizures .
• Reactions from the digestive system: nausea, abdominal cramps, vomiting,.

The risk of adverse reactions (especially of a neurotoxic nature) is higher in persons suffering from kidney failure .

Application instruction of Piperazine Adipinat (Way and dosage)

The instruction on Piperazine adipate recommends taking the drug for two consecutive days twice a day one hour before or one hour after meals. Single dose: for children under one year old is 200 mg, for children 2-3 years old is 300 mg, for children 4-5 years old is 500 mg, 6-8 years old is 750 mg, 9-12 years old is 1 g, 13-15 years is 1.5 g, for adults and children from 15 years old is 1.5-2 g.

At enterobiasis the drug is prescribed in identical dosages as during ascariasis. The course of therapy lasts five days. Spend up to three cycles of treatment with intervals of seven days between courses. Between courses at night, it is advised to do an enema with water and sodium bicarbonate (half a teaspoon of soda for 1 glass of water). For children, the volume of an enema includes up to three glasses of liquid, for adults - up to five glasses.

Piperazine adipate is actively used to treat domestic and farm animals. Instructions for use for animals prescribe to give the drug orally when uncinariasis, toxascariasis, trichuriasis And hookworm for two days at 100 mg/kg for cats and 200 mg/kg for dogs per day.

Overdose

Symptoms: impaired coordination, weakness, abdominal pain of a spastic nature. Individuals with impaired renal function may develop a number of neurotoxic events .

Therapy: gastric lavage with a suspension, taking saline laxatives, infusion therapy, oxygen therapy, symptomatic therapy. At neurotoxic symptoms use hydrochloride .

Interaction

When combined with aggravated extrapyramidal disorders.

Increases heaviness extrapyramidal disorders caused by phenothiazines (chlorpromazine ).

With simultaneous use with the antagonism of the effect on helminths is manifested.

Terms of sale

On prescription.

Storage conditions

• Keep away from children.
• Store in a dark dry place.

Best before date

Three years.

special instructions

Therapy with the drug does not require a specialized diet or preparation of the patient. With a tendency to constipation, laxatives may be prescribed.

During the treatment period enterobiasis a strict hygiene regime is recommended to improve the results of therapy.

Treatment with the drug is possible on an outpatient basis.

Debilitated patients and patients with anemia are advised to use the drug with caution.

Analogues

Coincidence in the ATX code of the 4th level:

Piperazine, Piperazine Adipinat Darnitsa.

During pregnancy and lactation

When taking the funds is prohibited. If during lactation it is necessary to take the drug, it () is interrupted for the period of treatment.

In the middle of the 20th century, doctors discovered the medicinal properties of piperazine, a substance whose use makes it possible to defeat many forms of helminthiases. Soon, based on the active component, drugs began to be produced.

Indications for use

1. First of all, the drug is prescribed for ascariasis and infection with pinworms.
2. Piperazine may be suitable for the treatment of other forms of roundworms that linger in the host due to muscle tone. But the drug cannot guarantee the correct result in such cases.

Due to its mild formula and gentle action, the remedy is suitable for children of any age, even babies, if the correct dosages are used and the treatment is prescribed by a doctor.

If the worms caught you during lactation, and you do not know what to do, the drug may be a way out. For pregnant and lactating women, treatment with Piperazine is not contraindicated, which makes it truly unique among analogues.

Method of administration and dosage

1. The tablet should be taken with water. Adults take twice a day, in general, no more than 4 mg of the active substance, one hour before meals or half an hour after eating. The course should be drunk in two days. No special diets are required during therapy.
2. For children from 12 to 15, tablets from worms are suitable in the same dosages, since the active components are excreted quickly and without a trace through the urinary system.
3. For persons from 9 to 12 years old, the dose is reduced to 2 g per day.
4. For children of primary school age, doctors prescribe 0.75 g at a time.
5. Kindergarten babies can also be given medicine, but not more than 0.4 g per day and with extreme caution.
6. Once a year, you can take a pill for prevention.

The correct dosage is adjusted by a specialist. Under certain indications, the doctor may also prescribe a one-day course of taking the drug with increases in the amount of active substance used.

Contraindications

Despite its low toxicity, the drug may be contraindicated in a number of disorders:

• nephritis, epileptic seizures, some diseases of the central nervous system;
• chronic kidney and liver diseases;
• allergy and individual intolerance to a number of components of Piperazine.

If you need to take chlorpromazine (trade name - Aminazine), before starting a course of treatment, you should do tests and consult a specialist who will tell you what to do next. Since Piperazine enhances the negative effects and side effects of a chemical that has a powerful antipsychotic effect.

Possible side effects

Piperazine can have a number of side effects:

• disorders in the gastrointestinal tract, accompanied by nausea and vomiting;
• patients with diseased kidneys may complain of increased fatigue, short-term blurred vision, impaired coordination of movement while taking pills;
• in rare cases, you may feel dizzy.

Since side effects should not occur during the normal course of treatment, their occurrence should be taken seriously. If, for example, you feel dizzy, then this should be the reason for an immediate appeal to your doctor.

Overdose can cause tremors and the above side effects. If for some reason you overdose, take activated charcoal. In case of serious complications, gastric lavage is prescribed.

Interaction with other drugs

The practice of using the drug has not found a decrease in the effectiveness of Piperazine when combined with other drugs. Also, the drug does not cause a threat to a person, however, a joint intake with Aminazin can cause extrapyramidal disorders: convulsions, difficulty in movement and other manifestations of a deterioration in muscle tone.

Cost and trade names

Piperazine-based drugs are among the cheapest among analogues. The average cost of a pack of tablets in the Russian market does not exceed 20-25 rubles. Today, the substance is available under the following trade names: Piperazine adipate, Piperazine.

Analogues

There are a large number of analogues of this drug. These include:

• Ditrazine, similar in its therapeutic effect, but with greater side effects;
• a good analogue that can be used in the treatment of ascariasis and excretion is Pirantel;
• Adipat is one of the few analogues that can be drunk by pregnant and lactating women;
• there are also a large number of preparations for helminthic invasions of complex effects: Dekaris, Nemozol and others.

In general, against the background of most of its analogues, Piperazine stands out for the absence of serious side effects and low price. However, its effectiveness is limited by its use against a narrow range of helminthiases.