Piperazine dosage. How to use piperazine for parasites. To rid children of ascariasis

Piperazine, aka piperazine adipate, is one of the oldest and most proven anthelmintic drugs. The date of the first registration of this tool falls on 1970. During its use, piperazine has established itself as a low-toxic drug substance with an extremely limited set of indications for use. The medicine is prescribed only for enterobiasis and ascariasis. With other helminthic invasions, the drug is not effective. To date, piperazine is considered obsolete, as it requires a long course of administration. Modern means with a similar effect are taken once.

pharmachologic effect

Important: piperazine adipate affects the sexually mature forms of helminths of both sexes, as well as their immature varieties. This ensures the high efficiency of the drug.

Piperazine adipate - the main active ingredient of the tablets "Piperazine" - a salt of a neutral nature, a white crystalline powder with a sour taste. Soluble in water and diluted alcohols. Practically insoluble in pure alcohol.

Instructions for use Piperazine

The dosage and regimen of piperazine varies depending on the disease diagnosed. Ascariasis requires a shorter course of therapy. With enterobiasis, treatment is longer.

For adults

For the treatment of helminthiases caused by roundworms, adult patients are prescribed a two-day course of therapy. In this case, the drug is taken twice a day, 1.5-2 grams (4 tablets of 0.5 grams). Piperazine is taken on an empty stomach, half an hour before meals or 2 hours after it.

Important: if rapid deworming is necessary, a single dose of piperazine at a dose of 4 grams is allowed. However, the chances of a complete cure are somewhat reduced, and the risk of side effects increases.

Enterobiosis requires complication of the therapeutic regimen. To get rid of pinworms, piperazine is taken for 5 days, 2 times a day on an empty stomach. The dose for admission is 2 grams. After the end of the first cycle, a seven-day break should be taken, and then the treatment should be repeated. To achieve success, 2-3 cycles should be carried out.

Piperazine can be used to treat children from birth. However, this requires careful dose adjustment. The dosage of the drug is calculated depending on the age of the patient.

Similar to the rules for the use of piperazine for adult patients, the treatment of ascariasis can be carried out by a single use of the drug at a dose twice the maximum single dose. This method of treatment is allowed only in children older than 7 years who tolerate the drug well. When using piperazine for the first time, children are advised to take the drug in accordance with the planned schedule.

Is it possible for pregnant and lactating mothers

Piperazine adipate is one of the few antihelminthics that can be used during pregnancy. Due to the low toxicity of the drug, gestation and lactation are not a contraindication for anthelmintic therapy.

If, as a result of treatment, a pregnant woman develops vague abdominal pain or constipation, it is better to stop therapy. In this case, it is necessary to completely abandon the use of chemical medicines, preferring sparing folk recipes.

Important: Piperazine during pregnancy continues to be used even in the presence of side effects, if the intended benefit to the mother's body is higher than the possible risk to the fetus. The woman makes this decision together with the attending physician after identifying the causes of the negative reaction.

piperazine and alcohol

Like any other medicine, piperazine is not recommended for use with alcohol. There are no data on the risk of developing disulfiram-like reactions with such a combination. However, drugs themselves significantly increase the load on the liver. Ethanol works the same way. The simultaneous negative impact of two factors can become critical and lead to disruptions in the work of the body.

The above is relevant only for high doses of ethyl alcohol, which are contained in alcoholic beverages. An anthelmintic drug is not harmful when used simultaneously with dosage forms that include ethanol. This is due to a small amount of alcohol consumed in 1 dose (literally a few drops).

Side effects

Side effects of piperazine adipate are extremely rare, usually when the dosing regimen is not followed. In this case, the patient may experience the following symptoms:

• nausea;
• vomit;
• vague abdominal pain;
• diarrhea;
• colic.

In some cases, it is possible to develop convulsions, impaired coordination, exacerbation of chronic renal diseases, confusion. To avoid this, before starting treatment, you should carefully study the instructions on how to take piperazine.

Contraindications

Piperazine should not be taken if, during its past use, the patient showed signs of allergic reactions or reactions of individual intolerance. In addition, the treatment of piperazine with adipinate should be abandoned in the presence of an organic pathology of the central nervous system. The drug has some effect on the conduction of the nerve impulse, which can provoke complications of the underlying disease.

Piperazine analogs

Piperazine has practically no direct analogues. Conventionally, these include such agents as adipalite, adiprazine, geltolan. However, all these agents are the same piperazine adipate. Depending on the manufacturer, only its trade names change.

In a more general sense, piperazine analogues are all existing antihelminthic drugs (mebendazole, albendazole, levamisole, pyrantel). However, each of them has its own indications and contraindications, its own active substance. Therefore, it is also wrong to call these drugs analogues of the agent in question.

This drug not only saves a person from ascariasis, but is also used in veterinary medicine to destroy worms in the intestines of animals.

Compound

Auxiliary components of the drug are starch, talc, calcium, sodium.

Due to the fact that the preparation contains practically no allergenic components, it can be taken even by people with frequent allergic reactions, in most cases it is well tolerated.

Release form

Piperazine is available in tablets and as a solution.

The tablet form is available in a blister of 6 or 10 pieces. Tablets can be in two dosages - 200, 500 mg of the active substance.

The solution is available in dark brown bottles, the volume of each bottle is 100 ml.

pharmachologic effect

Pharmacodynamics and pharmacokinetics

Piperazine from worms: indications for use

Piperazine is not the drug that is used for all helminthic diseases, it is prescribed only for enterobiasis and ascariasis. Therefore, if the patient needs to be treated for helminthiasis, he is prescribed another drug. However, if only helminth eggs are found in a child or an adult, then this drug is taken, so you can avoid poisoning the body with stronger pills when there is no urgent need to take them.

This medicine is also used to remove worms in animals.

Contraindications

Despite the fact that the drug is practically non-toxic, if the correct dosage is observed, it is not prescribed to all patients. Unlike other anthelmintic drugs, Piperazine for worms has few contraindications, and can be prescribed even to pregnant women and children, but in this case it is necessary to consult a doctor.

If patients have high sensitivity to the components of the drug or intolerance, it is also impossible to take it, otherwise unwanted allergic reactions may occur.

If a person has an organic lesion of the central nervous system, the medicine cannot be taken.

For people with renal insufficiency, Piperazine is contraindicated, since the drug is largely excreted in the urine, in some cases it can only be taken under medical supervision.

Side effects

Piperazine in the form of tablets can be prescribed to both adults and children, as the drug is easily tolerated and practically does not cause adverse reactions. Side effects may occur if Chlorpromazine is also taken during the treatment period. If a person has side effects from this medication, then they can be mild in the form of mild nausea, a slight headache, drowsiness, and when they are taken, the patient may have a stomach ache.

Rarely, if a person has kidney problems, the drug can cause poisoning. If the patient suffers from severe renal insufficiency, tremors of the limbs, hallucinations, temporary deterioration of vision, impaired coordination of movement, and muscle weakness may also occur, which is expressed in such a state of a person when you want to lie down or a person gets tired for no reason.

If adverse reactions in humans are mild, in this case, the drug is not canceled and the patient undergoes a full course of treatment. If a person has severe adverse reactions, it is necessary to stop taking the medicine and eliminate the symptoms. In this case, the doctor should choose a similar drug.

Adverse reactions in case of an overdose may include tremors in the limbs, weakness in the muscles, severe nausea, pain in the abdomen and head, vomiting, diarrhea or constipation. To treat such symptoms it is necessary to remove toxins from the body. The patient needs to take sorbents, sometimes the patient is prescribed laxatives, since this drug may cause constipation. If there is a severe poisoning with the drug, it is necessary to put a dropper or introduce Thiamine.

Piperazine: instructions for use for children and adults

If the patient has a tendency to constipation, then it is better to take laxatives during treatment with Piperazine, since this drug can cause constipation. Before taking Piperazine, you do not need to follow a specific diet or give up any type of food and nutrition in general.

It is best if the doctor prescribes the treatment with such a drug and sets the dosage, however, if the patient was previously dosed and treated with Piperazine, it can be taken again without warning the specialist.

From helminthiasis, the drug in the form of tablets is taken twice a day, while the dose at a time should be at least 1.5 and not more than 2 g, the daily dose of the drug should not exceed 3 g. The duration of treatment is three days. Depending on the type of settled worms, the drug can be taken for five days. If pinworms have settled in the intestines, the medicine is drunk all five days.

The pediatric dose of the drug is observed until the child is 16 years old. Until the age of three, the medicine should not be given in tablets, only injections are allowed, and only the doctor sets the dosage. Before taking Piperazine, the instructions for use should be studied, the dosage is indicated there by age.

Also, this drug can be used for prophylactic treatment twice a year, mainly in autumn and spring. For prophylaxis, the drug is given in the same doses as with conventional treatment. The medicine is prescribed to children less often than other anthelmintic drugs, since it has a narrow focus. Most often, for the prevention of helminthiasis, children are prescribed other drugs with a broader spectrum of action.

During pregnancy and lactation

The drug is allowed to be taken during pregnancy, but such treatment is carried out under the supervision of a physician. In this case, a completely different dosage is set. During lactation, the medicine can also be taken, but the child at this point must be transferred to artificial feeding, since the active substance can pass into breast milk.

Overdose

In case of an overdose, dizziness, nausea, vomiting, headache, abdominal pain, impaired attention, eye pain, diarrhea occur. In cases of overdose, symptomatic treatment is carried out.

Interaction

In most cases, the drug goes well with other drugs, but it is not recommended to take it simultaneously with Aminosine, as convulsions may occur, muscle tone may decrease, and movement may be difficult.

Tablets from worms Piperazine: special instructions

Without a doctor's prescription, the drug can be purchased at a pharmacy.

Piperazine tablets for worms are stored in a protected place from children and away from sunlight. The storage location must be dry. The drug can be stored for up to three years.

special instructions

The drug should not be treated longer than the prescribed period, and it should not be taken without interruption, this may cause an overdose and there will be visible side effects that will negatively affect the patient's health.

You should not treat the drug yourself for the first time, relying only on reviews or contraindications, as well as looking at the schemes. It should be taken into account that the treatment regimens are indicated in approximate dosages and the exact daily or single dose depends on the patient's age, weight and severity of the disease.

If there are constipations of a chronic nature, in this case, this remedy should be treated in parallel with taking laxatives.

During treatment with Piperazine, you should not drink alcoholic beverages, as well as other products that contain ethanol.

During pregnancy and breastfeeding, tablets from worms Piperazine should be taken only with the permission of the doctor and under his supervision. In general, women who are in position are allowed to take such a medicine, as experts have proven that the active substances do not affect the development of the fetus and do not have a negative effect on the body of a pregnant woman.

Analogues

Pirantel- an effective anthelmintic drug that kills worms and brings them out. Pirantel destroys the eggs of the worm, as well as those worms that lead to the development of anemia. The medicine fights against such types of worms as human roundworm, pinworms. The active substances of the drug block the motor ability of the worms, after which they die. Pirantel has contraindications, so the dosage should be selected only by a doctor.

Vermox- the medicine is prescribed for ascariasis, enterobiasis. The drug has a wide antimicrobial spectrum of action in helminthic invasions. It is prescribed for both adults and children.

Phytoglistocid- the remedy is used for all types of helminthic diseases, helps to restore the digestive tract, liver and pancreas. Relieves inflammation, replenishes the body with vitamins, minerals, flavonoids, essential oils.

Nemozol- a modern antihelminthic drug that quickly eliminates enterobiasis, destroys all types of worms, and also helps to cope with such diseases as opisthorchiasis, clonorchiasis. The drug is prescribed for adults and children. Before use, you must read the instructions, as the medicine is quite strong in its action.

Among experts, this drug is considered safe. If used correctly, there shouldn't be any problems. In addition, it does not lead to the absorption of decay products that are released during the death of helminths.

Warnings

No special preparations or other measures, such as dietary changes, fasting, avoidance of other drugs, administration of laxatives, are required during treatment with Piperazine.

Like other drugs, in some cases Piperazine is contraindicated. Children can only take it over the age of 3 years. For younger children, the doctor will choose a different medicine. In addition, they cannot be treated if the baby has impaired kidney, liver function, or pathologies of the central nervous system, for example, a convulsive disorder. You will have to choose another medication and with increased sensitivity to the active substance and other components in the composition of Piperazine.

Most parents agree that the use of Piperazine practically does not lead to side effects. If they occur, they may be as follows:

• headache;
• indigestion;
• nausea;
• vomit.

These adverse events can also occur if the drug is taken in the wrong dosage. In addition, the development of muscle weakness and trembling in the limbs is possible. In case of an overdose, it is necessary to make the child gastric lavage, give enterosorbents, such as activated charcoal.

But since Piperazine can be treated only as directed by a doctor, he will explain in detail how to take the medicine. If you follow the recommendations of a specialist, then you can not be afraid for the health of the child.

Dosage

The drug is taken orally, one hour before meals or half an hour after it. The amount of the drug needed to treat the baby depends on his age. So, a child from 3 years old is prescribed no more than 0.6 g of Piperazine per day. At the age of 4-5 years, up to 1 g is allowed. For the treatment of a 6-8-year-old child, 0.75-1 g per day is prescribed. Children 9–12 years old can take no more than 2 g. Adolescents are treated similarly to adult patients.

The duration of the course of treatment depends on the type of helminth that invaded the child's body. Therapy for ascariasis lasts 2 days, and the daily dose should be divided into 2 doses. Enterobiasis is treated within 5 days. To remove pinworms completely, the course is repeated in a week.

Piperazine is an anthelmintic. It has a paralyzing effect on nematodes, disrupting the function of their neuromuscular system.

Organic matter, refers to aliphatic cyclic amines, has a wide range of applications. Piperazine (as well as its salts) are widely used in medicine and veterinary medicine as an anthelmintic agent.

The drug is effective in ascariasis and enterobiasis. It has a paralyzing effect on nematodes: disrupting the function of their neuromuscular system, causes muscle paralysis.

The severity of deworming with the drug is at the level of 90-95%, and with repeated use it can be about 100%. Due to the fact that Piperazine does not destroy ascaris, there is no danger of absorption of biological toxic products of their decay. The drug has low toxicity.

Piperazine is produced in tablets and solution for children. During pregnancy, it is the only anthelmintic drug allowed for women during this period.

Indications for use

What helps piperazine? According to the instructions, the drug is prescribed in the following cases:

• Enterobiasis.
• Ascariasis.

Instructions for use Piperazine, dosage

The drug is taken orally.

Ascariasis

Piperazine for children is used in dosages:

• at the age of up to 1 year - 0.2 g (0.4 g / day);
• from 2 to 3 years - 0.3 g (0.6 g / day);
• from 4 to 5 years - 0.5 g (1 g / day);
• from 6 to 8 years - 0.75 g (1.5 g / day);
• from 9 to 12 years - 1 g (2 g / day);
• from 13 to 15 years - 1.5 g (3 g / day).

In the treatment of ascariasis, Piperazine can be prescribed 2 times a day 1 hour before or 30-60 minutes after meals for 2 consecutive days.

According to another scheme, the drug is prescribed for 1 day: depending on age, it is taken once at a dose of 0.4 g to 4 g or 2 times a day at a dose of 0.2 g to 2 g.

Piperazine with these helminthiases in adults is used according to the same schemes as in children. Doses for adults are: single - 1.5-2 g, daily - 3-4 g.

Enterobiasis

With enterobiasis, the drug is taken in the same doses, but longer - for 5 days. At the same time, to get rid of pinworms, it is necessary to go through 1-3 courses, between which week breaks are made.

Since Piperazine only paralyzes the worms and does not ensure their excretion, in order to avoid poisoning by their decay products, the instructions for use recommend removing helminths from the rectum with a cleansing enema. The enema solution is prepared from 200-600 ml of water and soda. For 100 ml of water, there are 0.25 teaspoons of soda.

With ascariasis, an enema is given after treatment, and with enterobiasis - between courses during each weekly break.

Application for animals

The drug is actively used to treat domestic and farm animals. Instructions for use of Piperazine for animals prescribe to give the drug orally for uncinariasis, toxascariasis, trichuriasis and hookworm infection for 2 days at 100 mg / kg for cats and 200 mg / kg for dogs per day.

special instructions

Deworming does not require a special diet or preparation. A laxative is prescribed only for a tendency to constipation.

During the treatment of enterobiasis, a strict hygienic regimen is observed. Treatment can be carried out on an outpatient basis.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Piperazine:

• Nausea, spastic abdominal pain, headache.
• In persons with renal insufficiency - neurotoxic complications (muscle weakness, tremor, euphoria, hallucinations, blurred vision, impaired coordination of movements).

Contraindications

Piperazine is contraindicated in the following cases:

• With lesions of the central nervous system of an organic nature;
• Chronic renal failure;
• With hypersensitivity.

The drug enhances the side effects of chlorpromazine.

Overdose

Symptoms of an overdose are a lack of coordination, tremor, weakness, abdominal pain of a spastic nature. In individuals with impaired renal function, a number of neurotoxic events may occur.

Gastric lavage with a suspension of enterosorbents, saline laxatives, infusion therapy, oxygen therapy, and symptomatic therapy are recommended. For neurotoxic symptoms, thiamine hydrochloride is used.