Why take Unidox Solutab. Unidox Solutab: instructions for use and what it is for, price, reviews, analogues. Unidox Solutab contraindications

In infectious diseases, doctors often prescribe the new generation antibiotic Unidox. The instruction recommends using this remedy for inflammatory processes caused by various microorganisms. The drug belongs to the group of tetracyclines and is able to act on a wide range of pathogens. The medicine not only destroys bacteria, but also prevents their further reproduction.

What is included in the tablets?

The active ingredient of Unidox is the tetracycline antibiotic doxycycline. The composition of each tablet includes 100 mg of this substance, it is it that has an antibacterial effect on the body.

The medicine also contains additional components: magnesium stearate, microcrystalline cellulose, hyprolose, lactose monohydrate, colloidal silicon dioxide. These substances do not have a therapeutic effect, but contribute to better absorption of doxycycline.

The medicine is released only in tablet form. In the pharmacy network, you can find the drugs Unidox and Unidox Solutab. The only difference between them is that Unidox Solutab tablets can be crushed, dissolved in water and prepared as a suspension. This form is convenient in the treatment of children. In all other respects, these drugs are absolutely identical.

The medication looks like round tablets, convex on both sides. The number 173 is engraved on them - this is the drug code.

How does an antibiotic work?

The medicine affects microorganisms at the cellular level. Doxycycline affects the RNA of harmful bacteria and inhibits the formation of microbial proteins. It is effective against many gram-positive and gram-negative bacteria: streptococci, staphylococci, treponema, salmonella, pathogens of many intestinal and genitourinary infections. In addition, it is able to destroy some of the simplest microorganisms - dysentery amoeba and Plasmodium (the causative agent of malaria).

However, with some infections, there will be no effect from the use of Unidox. The instruction says that doxycycline does not affect all types of viral and fungal microorganisms, as well as proteus, enterococci and Pseudomonas aeruginosa.

"Unidox" does not adversely affect the natural microflora of the digestive system and does not reduce immunity.

For what diseases is the drug prescribed?

If the patient is diagnosed with an infectious disease, the causative agent of which is susceptible to the effects of doxycycline, then the doctor may prescribe Unidox tablets. The use of an antibiotic is indicated for the following pathologies:

• otolaryngic infectious diseases (otitis media, sinusitis, sinusitis, tonsillitis, laryngitis, nasopharyngitis);
• respiratory pathologies caused by bacteria: bronchitis, pneumonia, tracheitis, lung abscess;
• gastrointestinal infections: gastroenteritis, cholecystitis, cholangitis, bacterial and yersiniosis;
• sexually transmitted diseases: syphilis, gonorrhea, chlamydia, inguinal and venereal granuloma;
• damage to the eyes of chlamydial infection (trachoma);
• tick-borne;
• whooping cough;
• sepsis;
• osteomyelitis;
• brucellosis;
• skin infections, acne;
• after operations for the prevention of purulent infection;
• urogenital cystitis, urethritis, endometritis, prostatitis, cervicitis, salpingo-oophoritis.

These are the most common indications for the appointment of the Unidox antibiotic. In addition, the drug is effective against especially dangerous infections and imported tropical diseases, such as:

• cholera;
• typhus (typhoid, typhus and relapsing);
• plague;
• malaria;
• legionellosis;
• Q fever;
• yaws;
• leptospirosis;
• spotted fever of the Rocky Mountains.

In some cases, it is possible to use Unidox tablets for prophylactic purposes. The instruction recommends prescribing the drug to people leaving for tropical countries in order to prevent infection with malaria and leptospirosis.

When is the drug contraindicated?

However, such an effective antibiotic as Unidox is not suitable for all groups of patients. First of all, it should not be taken by people with hypersensitivity to doxycycline and auxiliary components of the tablets. It should not be used by those patients who have previously experienced an allergy to tetracycline drugs.

There are other cases when the drug is categorically contraindicated. Tablets "Unidox" should not be taken by pregnant and lactating mothers. Doxycycline is able to overcome and also penetrate into breast milk. If a woman needs to undergo treatment during lactation, then breastfeeding should be stopped. This antibiotic is not prescribed for children under 8 years of age. Contraindications are due to the fact that doxycycline can accumulate in the bones and lead to calcium deposits in the skeleton of the fetus and young child. In addition, the drug can adversely affect the formation of teeth in children under 8 years of age.

Medicines with doxycycline are contraindicated in patients with severe pathologies of the liver and kidneys and in patients diagnosed with porphyria.

Unwanted drug effects

The body of some patients may react negatively to taking Unidox. Side effects may occur from the following organs and systems:

1. Central nervous system. Headache, intracranial hypertension, dizziness may disturb.
2. Gastrointestinal tract. Sometimes there are dyspeptic symptoms: nausea, vomiting, intestinal disorders, loss of appetite, some patients experience anorexia.
3. Skin covers. There are dermatitis, rashes, hyperemia. The photosensitivity of the skin increases.
4. Hematopoiesis: decrease in platelets and erythrocytes, increase in the number of eosinophils.
5. Other body systems. Oral or genital candidiasis may occur.

If such manifestations occur, they should be reported to the attending physician. After the dose is reduced or the antibiotic is discontinued, all side effects disappear.

How to take pills?

The attending physician, depending on the nature of the disease, determines the required dose of antibiotic. Reception "Unidox" is recommended during meals. Tablets are washed down with water. If the Unidox Solutab dosage form is used, then you can pre-crush and dissolve the tablets in 20 ml of water.

The following antibiotic treatment regimen is usually used:

1. For adult patients: on the first day, take 200 mg of the drug (2 tablets), divided into 2 doses. In the following days of the course of treatment, take 100 mg (1 tablet) of the drug per day. In severe infectious diseases, 200 mg of an antibiotic is prescribed per day throughout the entire therapy.
2. For children over 8 years old and weighing more than 50 kg, the treatment regimen is the same as for adults.
3. For children over 8 years of age weighing less than 50 kg, the dose is calculated based on body weight. On the first day, take 4 mg of medication per 1 kg of weight. In the following days of treatment, 2 mg of the drug is used per 1 kg of body weight (in 2 divided doses). In severe cases, the dosage of 4 mg / kg is maintained throughout the course of treatment.

Treatment with the drug usually lasts from 5 to 10 days. In some diseases, the duration of the course of therapy and the dosage of "Unidox" has its own characteristics:

1. When infected with pyogenic streptococcus, the course of treatment should last at least 10 days.
2. With syphilis, 2 tablets (200 mg per day) are prescribed for 14-28 days.
3. In the treatment of gonorrhea, chlamydia and ureaplasmosis of the genitourinary organs, it is recommended to take 2 tablets per day. The duration of therapy is about 7 days. In severe gonococcal infections, the dose may be increased to the maximum allowable - 300-600 mg per day, the course is 5 days.
4. In the treatment of acne on the skin, the drug is taken for a long time, from 6 to 12 weeks at a dosage of 100 mg per day.
5. For the treatment of leptospirosis, the antibiotic is taken at a dosage of 200 mg per day for a week. For the prevention of this disease, the drug is used at a dose of 200 mg once a week while staying in areas that are unfavorable for leptospirosis. Then take another 200 mg before departure.
6. For the prevention of malaria, take 100 mg of the drug 1 day before the trip, and then the same dose daily during the trip. After returning home, antibiotics should be continued at the same dosage for another 4 weeks.
7. 1 hour before a medical abortion, women take 1 Unidox tablet, and immediately after the intervention, they take 2 more tablets. This helps prevent infection.

It must be remembered that doxycycline greatly increases the sensitivity of the skin to ultraviolet radiation. Therefore, during the course of treatment, you should refuse to tan or use creams with a high degree of protection.

Compatibility with other medicines and alcohol

Some drugs may interfere with the absorption of doxycycline. These include antacids, iron preparations, laxatives with magnesium. Therefore, you need to maintain an interval of 3 hours between taking Unidox and these medicines.

It is undesirable to take vitamin A (retinol) during antibiotic treatment. This can cause headache due to increased intracranial pressure. And also, you should not combine the treatment of Unidox with the use of penicillin and cephalosporin antibiotics. These medicines will reduce the effect of doxycycline.

Women taking hormonal contraceptives should be aware that doxycycline reduces the contraceptive effect of these drugs and increases the likelihood of extracyclic uterine bleeding.

Patients should be aware that Unidox and alcohol are incompatible. Drinking alcohol enhances the metabolism of the drug, as a result, the concentration of the antibiotic in the blood plasma drops, and the therapeutic effect is reduced to zero. At the same time, a double burden falls on the liver, which manifests itself in nausea, vomiting, abdominal pain, diarrhea, and dizziness.

Barbiturates, Carbamazepine, Phenytoin, Rifampicin can also reduce the therapeutic effect of an antibiotic.

Terms of dispensing from pharmacies and storage rules

The drug is dispensed by prescription. You can not carry out self-treatment with the antibiotic "Unidox".

The instruction recommends storing tablets at a temperature of +15 to +25 degrees. To avoid poisoning, the medicine must be kept in a place where children cannot find it. At observance of rules of storage drug is suitable for the use of 5 years. After this period, the tablets should not be taken.

The price of tablets

The price of "Unidox" in pharmacies in Moscow is from 280 to 370 rubles. Currently, on sale you can mainly find Unidox Solutab tablets, which are a soluble form of the drug.

Drug analogues

Patients are often interested in Unidox analogues. You can pick up drugs with the same active ingredient - doxycycline. This category includes the following drugs:

• "Doxycycline".
• "Vibramycin".
• "Doxybene".
• "Xedocin".
• "Dovicin".
• "Doxylan".
• "Monoklin".
• "Basado".

Of these drugs, Doxycycline is the most common analogue of Unidox. Its price is very low - from 12 to 32 rubles.

Can Doxycycline be considered a full-fledged replacement for the soluble tablets Unidox Solutab? If we consider the chemical composition of these drugs, they contain different modifications of the same medicinal substance. "Doxycycline" is produced on the basis of hydrochloride, and "Unidox Solutab" - on the basis of monohydrate. They have the same therapeutic effect, but there are slight differences:

1. Soluble tablets (solutab) are better absorbed by the body.
2. Solutab tablets have fewer side effects, as they dissolve well and are absorbed in the intestine. "Doxycycline" begins its action while in the stomach, which often causes cramps and pain.
3. "Unidox Solutab" goes through several stages of purification during production and is a safer medicine.

It can be concluded that Doxycycline is a cheap analogue of Unidox and is somewhat more difficult to tolerate by the body.

Previously, the resistance of pathogenic flora to ongoing therapy was fought with the help of the synthesis of new potent antibacterial agents. But modern doctors have come to the conclusion that as a result of such therapy regimens, the effect of a "vicious circle" occurs. The patient drinks powerful antibiotics, and the resistance of bacteria is growing, respectively, even more “strong” drugs are required.

Therefore, in order to increase the effectiveness of treatment, it was proposed to produce long-known antimicrobial agents in a new dosage form, which can increase bioavailability and improve the distribution of the drug in the human body. Unidox Solutab, the instructions for use of which indicate the main active ingredient of the antibiotic, is available in the form of soluble tablets that meet all of the above requirements.

The active ingredient of the drug is an antibacterial compound from the group of tetracyclines doxycycline. It is a broad-spectrum antibiotic, it is active against gram-positive and gram-negative flora.

Moreover, they are also used for infections that are not amenable to therapy with other antibacterial agents (with the exception of tetracyclines).

To ensure the organoleptic properties and safety of the dosage form, as excipients in the composition of Unidox Solutab tablets, the instructions for use list: cellulose, sucrose, dioxide, magnesium stearate and other neutral compounds.

This drug is available in the form of dispersed tablets. The main principle of the Solutab technology is the controlled release of the drug due to microparticles, which consist of an active component that is associated with neutral excipients. After swallowing a whole or dissolved tablet, after about 10 to 30 seconds, the granules are evenly distributed throughout the digestive tract, and the release and absorption of doxycycline, which is part of Unicos Solutab, begins. The advantage of dispersible tablets is the absence of a residual concentration of the antibiotic in the intestine, which reduces the likelihood of side effects from the digestive system.

Compared with other analogues of doxycycline in the form of conventional capsules, Unidox Solutab, the instructions for use of which contain a detailed description of how to drink the medicine correctly, has a number of differences:

• a smooth increase in the concentration of the active substance in the blood;
• minimal impact on the physiological microflora of the gastrointestinal tract;
• a convenient way to use, since Unidox Solutab tablets can be drunk whole or pre-dissolved in ordinary water, it is strictly forbidden to dilute the medicine with mineral water, juices and alcohol;
• no risk of overdose.

Doxycycline has a bacteriostatic effect on pathogenic flora. The drug penetrates into the bacterial cell, accumulates there and interrupts the process of protein synthesis by ribosomes. The active component of this drug can only pass through the membrane of a pathogenic microorganism without affecting healthy human tissues.

Unidox Solutab, as, by the way, and its other analogues containing doxycycline, are also active against more exotic and rare bacteria. Indications for its appointment are infrequent infections, such as anthrax, typhoid, tetanus, gas gangrene, hemorrhagic septicemia. Despite the fact that in pharmacies the price of dispersible tablets is higher than for other dosage forms of doxycycline, according to doctors and patients, Unidox Solutab is more effective. However, contraindications to its use are the same as those of other antibiotics from the tetracycline group.

Dosage of Unidox Solutab: features of pharmacokinetics, indications, overdose and interaction with other drugs

When ingested dispersible tablets, the active substance is completely absorbed from the digestive tract (bioavailability is almost 100%). Despite the fact that food does not affect the degree of adsorption of doxycycline, the antibiotic is recommended to be taken with meals to avoid irritation of the mucous epithelium of the gastrointestinal tract.

The therapeutic dosage of Unidox Solutab in the blood serum (it is 2.5 - 3 μg / l) is achieved within 2 hours after taking the tablet. After 30-40 minutes, doxycycline is found in the focus of infection.

The drug does not penetrate the blood-brain barrier, but passes through the membrane of the placenta and is excreted along with breast milk.

The half-life of the drug is up to 18 hours with a single dose and 22 - 25 hours with a second dose. Almost half of the dose of the antibiotic taken is excreted unchanged by the kidneys, the rest of the drug binds to calcium and other trace elements (such structures are called chelates) and is excreted through the intestines.

The dosage of Unidox Solutab is selected depending on the type of infectious agent and the individual characteristics of the patient.

An antibiotic is prescribed to treat the following diseases:

• sexually transmitted infections (gonorrhea, syphilis, ureaplasmosis, chlamydia);
• dermatological lesions (acne, rosacea, acne infected with sensitive microflora);
• bacterial inflammation of the upper and lower respiratory tract (sinusitis, otitis media, pneumonia, bronchitis, whooping cough);
• gynecological and urological infections (adnexitis, endometritis, acute and chronic prostatitis);
• intestinal disorders of an infectious nature;
• severe systemic bacterial diseases (anthrax, borreliosis, rickettsiosis, typhus and typhoid fever, plague, tularemia, etc.);
• wounds, burns, animal and insect bites complicated by the addition of infectious inflammation;
• systemic bacterial pathologies (sepsis, peritonitis);
• lesions of the pathogenic flora of the muscular membrane of the heart (endocarditis, myocarditis, pericarditis);
• prevention of postoperative complications.

If the dosage of Unidox Solutab is not properly observed, complications associated with impaired functioning of liver cells are possible. There is a feeling of nausea, vomiting, yellowing of the skin and sclera caused by jaundice, blood clotting decreases. There is no specific pharmacological treatment for an overdose of Unidox Solutab.

Dispersible tablets are rapidly absorbed from the digestive tract, therefore, although it is recommended to do a gastric lavage, give an adsorbent and a laxative, such measures are ineffective. Does not bring results and hemodialysis. Carry out symptomatic therapy aimed at maintaining liver function.

Unidox Solutab is not combined with other antibiotics with bactericidal properties. The fact is that they change the structure of the cell wall of a growing bacterium, and doxycycline inhibits the reproduction of microorganisms. Therefore, the effect of the use of antimicrobial drugs is significantly reduced.

In addition, even the standard dosage of Unidox Solutab requires correction of the anticoagulant regimen. Gynecologists warn that under the influence of this antibiotic, the contraceptive activity of estrogen-based birth control pills decreases.

Drugs that stimulate the processes of microsomal oxidation accelerate the excretion of doxycycline. These are tricyclic antidepressants, antipsychotics, antiarrhythmic drugs, narcotic analgesics. Concurrent use of multivitamin complexes containing retinol can lead to an increase in intracranial pressure and corresponding clinical symptoms.

Unidox Solutab: how to take children and adults, features of use during pregnancy and lactation

For most infections caused by doxycycline-susceptible bacteria, 200 mg per day is prescribed once, and then this amount of the drug is reduced to 100 mg until the end of therapy.

In severe persistent disease, Unidox Solutab should be taken at 200 mg per day. The average duration of therapy is from 5 to 12 - 14 days.

However, some pathologies of a bacterial nature require a special approach:

• With prostatitis. The daily dosage of tablets is 200 mg. It is divided into two doses.
• With actinomycosis and complicated acne. The medicine is taken at 0.1 - 0.2 g per day for 1 month or more.
• For the prevention of postoperative complications. Drink 100 mg of the drug one hour before surgery and 200 mg after it.
• For gonorrhea. In an uncomplicated course - 600 mg, divided into two doses. Treatment continues only 1 day. With severe symptoms, the drug is prescribed in a standard dosage.

For children from 8 to 12 years old (provided that the weight of the child does not exceed 50 kg, otherwise Unidox Solutab should be taken at an adult dosage) the recommended amount of the drug is 4 mg / kg on the first day of treatment, then 1 mg / kg twice in a day. In severe bacterial inflammation, the child is given 4 mg / kg per day until the end of therapy.

Dispersible tablets can be dissolved immediately before taking in a small volume of water (20-30 ml) until a homogeneous suspension is obtained, chewed or crushed, or drunk whole. Take the medicine with food. It is not recommended to drink Unidox Solutab lying down to prevent erosive lesions of the intestinal mucosa.

Doxycycline crosses the placental barrier and is excreted in breast milk. Therefore, the use of Unidox Solutab for the treatment of bacterial infections during pregnancy and lactation is contraindicated. Taking the medicine can cause irreversible damage to the musculoskeletal system of the fetus or child who is breastfed.

Unidox Solutab: side effects, contraindications, analogues, special instructions

In addition to pregnancy and lactation, there are other contraindications to taking doxycycline in the form of dispersible tablets, these are:

• early age, the medicine is not recommended for children under 8 years of age (some medical sources indicate a different age - 9 years) due to the high risk of calcium metabolism disorders;
• porphyria;
• severe manifestations of renal and hepatic insufficiency;
• individual intolerance to any antibiotics from the tetracycline group.

The use of a new dosage form of doxycycline minimizes the likelihood of adverse reactions. However, the manufacturer is obliged to warn about the complications of treatment, even if the risk of their development is negligible.

So, against the background of taking Unidox Solutab, side effects can manifest themselves in the form of the following symptoms:

• nausea, vomiting, loss of appetite, constant feeling of a full stomach, diarrhea, dysphagia (swallowing disorder), inflammation of the intestinal mucosa (enterocolitis or pseudomembranous colitis);
• with violations of the liver, signs of jaundice may appear;
• the occurrence of a rash with prolonged exposure to the sun;
• urticaria, skin itching and swelling;
• incoordination, headache, dizziness, blurred vision, drowsiness;
• with prolonged use due to the accumulation of doxycycline, a brown tint may appear on the tooth enamel.

Like most other broad-spectrum antibiotics, this drug can be purchased at any pharmacy or ordered with targeted delivery via the Internet. Store the medicine package in a dry, dark place at room temperature. The expiration date is indicated on the cardboard box and blister with tablets and is 5 years.

When taking Unidox Solutab, side effects can be minimized, subject to additional recommendations from doctors.

They come down to this:

• If the doctor has prescribed to drink the drug twice a day, it is necessary to observe a 12-hour interval between taking the medicine.
• Do not take tablets just before bed.
• When taking Unidox Solutab for a long time, you should regularly take clinical blood and urine tests.
• At the time of treatment, it is necessary to limit exposure to the open sun, you can not sunbathe and 4-5 days after the end of taking the pills.
• In case of impaired renal function, therapy is carried out in a hospital setting.
• During treatment, a woman should use means to prevent pregnancy.
• Before starting therapy, it is necessary to warn the doctor about taking other drugs, since their interaction with doxycycline can cause serious complications.
• If on the 4th - 5th day of therapy a high temperature and other symptoms of the disease persist, this may indicate the resistance of the bacterial flora and requires the replacement of Unidox Solutab with another antibiotic.
• Doxycycline has a certain anti-inflammatory activity, however, other drugs from the NSAID group are additionally prescribed for the treatment of prostatitis in men.

There are no analogues of Unidox Solutab, which would have the same composition and release form.

This medicine can be replaced with conventional Doxycycline or preparations containing it:

• Vibramycin;
• Doxylan;
• Vidoccin;
• Monoclin.

According to doctors, Unidox Solutab, whose side effects are less pronounced than other forms of doxycycline, is prescribed for allergies or ineffectiveness of penicillin antibiotics. Moreover, when prescribing treatment, dispersible tablets are strongly recommended. The cost of a package of 10 pills containing 100 mg of doxycycline is 320 - 350 rubles.

The drug Unidox Solutab is an antibiotic agent of the tetracycline group with a wide spectrum of antimicrobial effects. The drug is applicable for the treatment of many infectious lesions of various body systems caused by pathogenic microorganisms sensitive to the action of the active component. The agent has a pronounced bacteriostatic effect. Unidox Solutab can be taken from the age of 8, which greatly expands the therapeutic possibilities of the drug. To achieve the most effective result, the calculation of individual dosages should be entrusted to a qualified specialist.

Dosage form

The antimicrobial agent Unidox Solutab is available in the form of round grayish-yellow biconvex dispersible tablets with the engraved code "173" on one side and a notched dividing strip on the other.

The medication is packed in cardboard packs containing one blister of 10 tablets.

Description and composition

The active ingredient of the antibiotic Unidox Solutab is represented by monohydrate. Each medicinal unit of the drug contains 100 mg of the active element.

As auxiliary substances are:

• anhydrous silica;
• magnesium stearate;
• hypromellose;
• lactose monohydrate;
• saccharin;
• cellulose microcrystalline.

Pharmacological group

Unidox Solutab belongs to the group of antimicrobial drugs of the tetracycline series with a pronounced bacteriostatic effect. Medicinal activity consists in disruption of metabolic processes and interruption of protein synthesis in the cell membranes of pathogenic microorganisms. In addition, the substance helps to break the bonds of certain types of RNA with ribosomal membranes. exhibits increased activity against developing and dividing bacteria. The agent has practically no effect on the microflora, which is at rest. The bacteriostatic effect is observed against a wide range of pathogenic microorganisms. Some gram-positive, gram-negative and various bacteria that cause sexually transmitted infections are susceptible to action.

Unidox Solutab shows a high degree of absorption from the gastrointestinal tract, which is not affected by food intake. The possibility of binding to serum proteins averages 90%. The concentration of the active substance in plasma reaches a maximum after 2-3 hours after oral administration.

Hepatic metabolism produces both active and inactive metabolites. Excretion of active metabolic products and unchanged occurs in the urine, while inactive metabolites are excreted in the feces. The half-life is from 16 to 18 hours. When you take the medicine again, this time increases by 3-4 hours.

The active substance of Unidox Solutab can penetrate the placental barrier and pass into breast milk. The drug accumulates in the tissues of the prostate gland.

Indications for use

The agent is prescribed for the treatment of infectious diseases caused by a wide range of pathogenic microorganisms susceptible to action.

for adults

Infections of the gastrointestinal tract and biliary tract:

• traveler's diarrhea;
• cholera;
• cholecystitis;
• amoebic dysentery;
• cholangitis;
• gastroenterocolitis.

Urinary tract infections:

• urethritis;
• chlamydia;
• syphilis;
• gonorrhea (as an alternative treatment);
• lymphogranuloma of a venereal nature;
• urogenital mycoplasmosis;
• bacterial prostatitis.

ENT infections:

• sinusitis;
• tonsillitis.

Other infections:

• acute degree of infectious;
• malaria;
• severe form of acne;
• infectious lesions after animal bites;
• plague;
• peritonitis;
• whooping cough;
• lung abscess;
• actinomycosis;
• eye infections;
• sepsis.

for children

Children under the age of 8 years are prohibited from using Unidox Solutab due to the extremely negative effect of the active element of the drug on the growth and development of the child's skeletal bones and teeth.

The medication may pass into breast milk. If it is necessary to use the drug during lactation, it is necessary to stop breastfeeding the child.

During pregnancy, the use of the drug is strictly prohibited due to the possibility of passing through the placenta.

Contraindications

• age group of patients up to 8 years;
• pregnancy and GC period;
• acute form of renal and / or liver failure;
• increased susceptibility of the patient's body to tetracyclines.

Applications and doses

For the fastest and most effective achievement of therapeutic goals, it is recommended to draw up the average daily dosages and the medication regimen together with the attending physician.

The tablets can be taken whole or crushed. Drink the product with plenty of clean water.

for adults

Adult patients and children over 8 years old, whose body weight exceeds 50 kg, are prescribed the initial dose of Unidox Solutab at a dosage of 100 mg 2 times a day or 200 mg 1 time per day. From the second day until the end of the course, the average daily dose should be 100 mg. In severe types of diseases, the initial dosage remains unchanged.

for children

The use of the drug for children under 8 years of age is strictly contraindicated.

The age group over 8 years old, with a body weight of not more than 50 kg, is recommended to take the medication in the following dosages:

• on the first day, the dose should be 4 mg per kg of the child's weight;
• the following doses of medication are 2 mg per kg of body weight.

In case of severe infectious pathologies, the initial dosage does not change throughout the entire therapeutic course.

for pregnant women and during lactation

Pregnant and lactating women are contraindicated in the use of this medication. If necessary, use during the GV period, you should immediately stop breastfeeding the baby.

Side effects

• decrease in prothrombin time;
• nausea;
• the development of diseases of a candidal nature;
• various stool disorders;
• dermatitis;
• thrombocytopenia;
• tongue inflammation;
• increased intracranial pressure;
• the appearance of an itchy rash on the skin;
• dizziness;
• enterocolitis;
• increased sensitivity to ultraviolet or visible radiation;
• angioedema;
• anemia.

Interaction with other drugs

The appointment of Unidox Solutab in conjunction with cephalosporins, antibiotic drugs of the penicillin series and other drugs that have a bactericidal effect is contraindicated.

Also, simultaneous use with antacids and other metal-containing agents is undesirable due to the possibility of the formation of inactive compounds due to a chemical reaction.

It is possible to change the prothrombin index when used together with anticoagulants.

Colestipol and cholestyramine reduce the absorption of the drug.

When taken simultaneously with retinol, a significant increase in intracranial pressure is possible.

The drug reduces the effectiveness of oral contraceptives and increases the frequency of uterine bleeding that occurs against the background of their use.

special instructions

If the patient has various disorders of kidney function, no additional adjustments of drug dosages are required.

The drug can provoke underdevelopment of tooth enamel and significantly slow down the longitudinal growth of skeletal bones in children under 8 years of age.

In liver disease, special care must be taken.

To prevent the irritating effect of the drug on the mucous membranes of the gastrointestinal tract, it is recommended to take the drug in the middle of the day with a sufficient amount of liquid.

Overdose

Symptoms of an overdose with increased doses of Unidox Solutab are:

• diarrhea;
• seizures;
• anorexia;
• feeling dizzy;
• nausea;
• pain in the head.

If signs of intoxication occur, it is necessary to immediately take a sufficient amount of enterosorbents, rinse the stomach and begin symptomatic treatment.

Analogues

Instead of Unidox Solutab, you can use the following drugs:

1. - a domestic drug, which is produced by a number of Russian companies. It is on sale in capsules (allowed for patients over 12 years old, whose weight is more than 45 kg) and lyophilisate from which an infusion solution is prepared (it is possible from 8 years old). The antibiotic is contraindicated in pregnant and lactating women.
2. Xedocin is a German drug that is a complete analogue of Unidox Solutab. The antibiotic is produced in capsules that are contraindicated in children under 8 years of age, in position and breastfeeding patients.
3. Vidoccin is a domestic medicine based on which is produced in a lyophilisate, when it is diluted, a solution for intravenous administration is obtained. The medicine is prohibited for children under 8 years of age, pregnant and lactating.
4. Minoleksin is a substitute for the drug Unidox Solutab according to the pharmacological group. An antibiotic is produced in capsules, approved for children over 8 years old, pregnant patients. At the time of taking the medication, it is recommended to interrupt breastfeeding.

Storage conditions

The medication should be stored in a dry, dark place at a temperature not exceeding 25 degrees. It is necessary to limit the access of children to the drug.

Shelf life - 5 years.

The price of the drug

The cost of the drug is an average of 322 rubles. Prices range from 283 to 367 rubles.

In this article, you can read the instructions for the use of an antibacterial drug Unidox Solutab. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Unidox Solutab in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Unidox Solutab analogues in the presence of existing structural analogues. Use for the treatment of bronchitis, otitis, ureaplasma and other infections, as well as acne in adults, children, as well as during pregnancy and lactation.

Unidox Solutab- long-acting tetracycline (active substance - antibiotic doxycycline) with a wide spectrum of action. It acts bacteriostatically, inhibits protein synthesis in the microbial cell.

Active against gram-positive and gram-negative aerobic and anaerobic bacteria.

The possibility of acquired resistance to doxycycline in a number of pathogens should be taken into account, which is often cross-group within a group (i.e. strains resistant to doxycycline will simultaneously be resistant to the entire group of tetracyclines).

Pharmacokinetics

Absorption - fast and high (100%). Food intake slightly affects the absorption of the drug, which has no clinical significance. Doxycycline binds reversibly to plasma proteins (80-90%), penetrates well into tissues, poorly into cerebrospinal fluid (10-20% of plasma concentration), however, the concentration of doxycycline in cerebrospinal fluid increases with inflammation of the spinal membrane. Doxycycline crosses the placental barrier and is secreted in small amounts into breast milk. Only a small part of doxycycline is metabolized. Approximately 40% of the dose taken is excreted in a biologically active form by tubular secretion in the kidneys, 20-40% is excreted through the intestines in the form of inactive forms (chelates).

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• respiratory infections (including pharyngitis, acute bronchitis, exacerbation of chronic obstructive pulmonary disease, tracheitis, bronchopneumonia, lobar pneumonia, community-acquired pneumonia, lung abscess, pleural empyema);
• infections of ENT organs (including otitis media, sinusitis, tonsillitis);
• infections of the genitourinary system (cystitis, pyelonephritis, bacterial prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, acute orchiepididymitis; endometritis, endocervicitis and salpingo-oophoritis / as part of combination therapy /);
• sexually transmitted infections (urogenital chlamydia, syphilis in patients with intolerance to penicillins, uncomplicated gonorrhea / as an alternative therapy /, inguinal granuloma, venereal lymphogranuloma);
• infections of the gastrointestinal tract and biliary tract (cholera, yersiniosis, cholecystitis, cholangitis, gastroenterocolitis, bacillary and amoebic dysentery, travelers' diarrhea);
• skin and soft tissue infections (including wound infections after animal bites), severe acne (as part of combination therapy);
• other diseases (yaws, legionellosis, chlamydia of various localization / including prostatitis and proctitis /, rickettsiosis, Q fever, Rocky Mountain spotted fever, typhoid / including typhus, tick-borne relapsing /, Lyme disease / stage 1 - erythema migrans/, tularemia, plague, actinomycosis, malaria, leptospirosis, psittacosis, ornithosis, anthrax /including pulmonary form/, bartonellosis, granulocytic ehrlichiosis, whooping cough, brucellosis);
• infectious eye diseases, as part of combination therapy - trachoma;
• osteomyelitis;
• sepsis;
• subacute septic endocarditis;
• peritonitis.

Prevention of postoperative purulent complications and malaria caused by Plasmodium falciparum during short-term travel (less than 4 months) in areas where strains resistant to chloroquine and / or pyrimethamine-sulfadoxine are common.

Release form

Dispersible tablets 100 mg.

Instructions for use and dosing regimen

The drug is preferably taken with meals. The tablets are dissolved in a small amount of water (about 20 ml) to form a suspension. Tablets can also be swallowed whole, divided into parts or chewed with water. Usually the duration of treatment is 5-10 days.

Adults and children over 8 years of age weighing more than 50 kg on the first day of treatment are prescribed 200 mg per day in 1 or 2 doses, on subsequent days of treatment - 100 mg per day in 1 dose. In case of severe infections, 200 mg per day is prescribed for the entire period of treatment.

For children aged 8-12 years weighing less than 50 kg, the average daily dose is 4 mg / kg on the first day, then 2 mg / kg per day (in 1-2 doses). In cases of severe infections, the drug is prescribed at a dose of 4 mg / kg daily during the entire treatment.

With an infection caused by Streptococcus pyogenes, the duration of treatment is at least 10 days.

In uncomplicated gonorrhea (with the exception of anorectal infections in men), adults are prescribed 100 mg 2 times a day until complete recovery (on average within 7 days), or 600 mg is prescribed for one day - 300 mg in 2 doses (second dose 1 hour after the first).

For primary syphilis, 100 mg 2 times a day for 14 days is prescribed, for secondary syphilis, 100 mg 2 times a day for 28 days.

For uncomplicated urogenital infections caused by Chlamydia trachomatis, cervicitis, non-gonococcal urethritis caused by Ureaplasma urealiticum, 100 mg is prescribed 2 times a day for 7 days.

For acne, 100 mg per day is prescribed, the course of treatment is 6-12 weeks.

For the prevention of malaria, 100 mg is prescribed 1 time per day for 1-2 days before the trip, then daily during the trip and within 4 weeks after returning; children over 8 years old - 2 mg / kg 1 time per day.

For the prevention of travelers' diarrhea - 200 mg on the first day of the trip in 1 or 2 doses, then - 100 mg 1 time per day during the entire stay in the region (no more than 3 weeks).

For the treatment of leptospirosis - 100 mg orally 2 for 7 days; for the prevention of leptospirosis - 200 mg once a week during a stay in a disadvantaged area and 200 mg - at the end of the trip.

In order to prevent infections during medical abortion, 100 mg is prescribed 1 hour before and 200 mg after the intervention.

The maximum daily dose for adults is up to 300 mg per day or up to 600 mg per day for 5 days in severe gonococcal infections. For children over 8 years old weighing more than 50 kg - up to 200 mg, for children 8-12 years old weighing less than 50 kg - 4 mg / kg daily during the entire treatment.

With renal (CC less than 60 ml / min) and / or liver failure, a decrease in the daily dose of doxycycline is required.

Side effect

• anorexia;
• nausea, vomiting;
• dysphagia;
• diarrhea;
• enterocolitis;
• pseudomembranous colitis;
• photosensitivity;
• hives;
• angioedema;
• anaphylactic reactions;
• hemolytic anemia;
• thrombocytopenia;
• neutropenia;
• eosinophilia;
• candidiasis (glossitis, stomatitis, proctitis, vaginitis) as manifestations of superinfection.

Contraindications

• severe violations of the liver and / or kidneys;
• porphyria;
• pregnancy;
• lactation period (breastfeeding);
• children's age up to 8 years;
• hypersensitivity to antibiotics of the tetracycline group.

Use during pregnancy and lactation

Unidox Solutab is contraindicated for use during pregnancy.

The drug is contraindicated for use during lactation (breastfeeding). Doxycycline is excreted in breast milk.

special instructions

There is a possibility of cross-resistance and hypersensitivity with other tetracycline drugs.

Tetracyclines can increase prothrombin time, the use of tetracyclines in patients with coagulopathy should be carefully monitored.

The antianabolic effect of tetracyclines can lead to an increase in the level of residual urea nitrogen in the blood. As a rule, this is not significant for patients with normal kidney function. However, in patients with renal insufficiency, there may be an increase in azotemia. The use of tetracyclines in patients with impaired renal function requires medical supervision.

With prolonged use of the drug, periodic monitoring of laboratory blood parameters, liver and kidney function is required.

In connection with the possible development of photodermatitis, it is necessary to limit insolation during treatment and for 4-5 days after it.

Prolonged use of the drug Unidox Solutab can cause dysbacteriosis and, as a result, the development of hypovitaminosis (especially B vitamins).

To prevent dyspeptic phenomena, it is recommended to take the drug during meals.

Influence on the ability to drive vehicles and control mechanisms

Features of the impact on the ability to drive a car and operate mechanisms have not been studied.

drug interaction

In connection with the suppression of intestinal microflora by doxycycline, the prothrombin index decreases, which requires dose adjustment of indirect anticoagulants.

When doxycilin is combined with bactericidal antibiotics that disrupt the synthesis of the cell wall (penicillins, cephalosporins), the effectiveness of the latter decreases, which should be taken into account in the treatment of meningitis and tonsillopharyngitis caused by Streptococcus pyogenes.

Doxycycline reduces the reliability of contraception and increases the frequency of acyclic bleeding when taking estrogen-containing hormonal contraceptives.

Ethanol (alcohol), barbiturates, rifampicin, carbamazepine, phenytoin, accelerating the metabolism of doxycycline, reduce its concentration in blood plasma.

The simultaneous use of doxycycline and retinol increases intracranial pressure.

Analogues of the drug Unidox Solutab

Structural analogues for the active substance:

• Bassado;
• Vibramycin;
• Vidoccin;
• Dovicin;
• Doxal;
• Doksibene;
• Doxylan;
• doxycycline;
• Doxycycline Nycomed;
• Doxycycline Stada;
• Doxycycline-AKOS;
• doxycycline hydrochloride;
• Xedocin;
• Monoclin.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

- a powerful broad-spectrum antibiotic. The drug belongs to the subcategory of tetracyclines, it has a depressing effect on the pathogenic flora. The medicine is used mainly in gynecology, ophthalmology and otolaryngology. With the help of this tool, the prevention of suppuration of wounds in the postoperative period is carried out.

– an effective drug with a wide range of applications

Release form and composition of Unidox

The medication is available in the form of tablets. One package contains ten pieces. The tablets are odorless, have a yellowish coating. The blisters are in lightweight cardboard packaging.

The tablet contains 100 mg of the active ingredient - doxycycline. This substance is a semi-synthetic antibiotic. Doxycycline is effective for the treatment of gram-negative and gram-positive pathogens.

Additional components:

• cellulose;
• sweetener;
• magnesium stearate;
• lactose monohydrate (as a base);
• silicon dioxide (colloidal anhydrous).

The drug contains many chemical elements, so it can cause an allergic reaction in people with hypersensitivity. The tool is manufactured by Astellas.

Unidox Solutab contains the substance doxycycline

Price and analogues of the drug

The average cost of the drug is 350 rubles. On the Internet, you can buy Unidox Solutab a little cheaper – for 310 – 340 rubles. The medicine is also sold in pharmacies, dispensed by prescription.

The main analogues of the drug (products containing doxycycline as an active ingredient):

1. Vidoccin. It is produced in the form of a lyophilizate (means for the preparation of a medicinal suspension). Contraindicated in patients under 8 years of age, pregnant and lactating women. The drug can be drunk or injected with it. The main advantage of the drug is that it can be stored indefinitely. The price of the medication: from 80 rubles.
2. Xedocin. Produced in tablet form. Tablets labeled A6 contain 100 mg of the active substance (per 1 piece). The drug marked A7 has a high content of the active ingredient (200 mg per tablet). The drug is prohibited for use by children, pregnant and lactating women. The tool is not recommended for leukopenia, porphyria and severe liver failure. The cost of the medicine: from 200 rubles.
3. Doxycycline. Available in the form of capsules and lyophilisate. It is not used to treat children under 12 years of age, as well as pregnant and lactating women. 1 capsule contains 100 mg of the active ingredient. The drug is effective for acne and acne. The lyophilisate can be used for the treatment of children over 8 years of age. The cost of the drug: from 30 to 250 rubles (depending on the place of purchase and form of release).

Can Unidox Solutab be used to treat acne? Yes, the drug is able to cure various bacterial rashes. You can look at the before and after photos on the Internet to see for yourself the effectiveness of the product. But keep in mind that this medicine is not suitable for everyone.

Unidox Solutab can cure acne

Indications for the use of Unidox

With the help of the drug, infectious and inflammatory diseases that have arisen against the background of pathogenic microflora are treated. The tool destroys bacteria such as Klebsiella, Salmonella, Staphylococcus aureus.

What helps? General indications for use:

• otolaryngological infections (in particular, sinusitis, tonsillitis, otitis media);
• diseases of the genitourinary system (urethritis, bacterial prostatitis, cystitis);
• diseases of the respiratory system (acute bronchitis, pneumonia, pharyngitis);
• sexually transmitted pathologies (the drug shows high efficiency in ureaplasma, syphilis and chlamydia);
• diseases of the gastrointestinal tract and biliary organs (cholangitis, cholera, amoebic and bacillary dysentery);
• skin infections and soft tissue lesions (particularly severe acne).

The drug Unidox Solutab fights pathogenic microflora

Unidox is part of the complex therapy for infectious eye diseases. The drug is used to treat purulent-necrotic processes occurring in bone tissues. The drug is used to prevent various postoperative complications.

The drug can be used to treat ulcers of various localization. Before use, be sure to consult a doctor.

Pharmacological action of tablets

With prolonged use of the drug, pathogenic microorganisms develop tolerance to the entire group of tetracyclines.

The drug is absorbed by 90 – 95% (average) in 2 hours. Food has no effect on the absorption of the drug, so you can eat before and after taking the medication. Maximum concentration of the active substance in the blood: 2.5 – 3 mg per 1 ml. After 24 hours, the doxycycline level drops to 1.2 – 1.4 mg per 1 ml. The drug is excreted through the kidneys and intestines.

The drug can be taken before and after meals.

Instructions for use Unidox Solutab

The daily dose of the drug depends on the age of the patient, as well as on the type and stage of development of the disease. In hepatic or renal insufficiency, the dosage should be reduced, as there is a risk of excessive stress on these organs. The drug accumulates in the body and has a hepatotoxic effect.

Average duration of therapy – from 5 to 12 days.

Adults and children weighing over 50 kg are prescribed a constant daily dose of 100 mg, on the first day of admission - 200 mg. For advanced and severe infections, the daily dosage throughout the treatment is 200 mg.

Dose for patients from 8 years old weighing up to 50 kg – 4 mg per 1 kg on the first day of therapy, 2 mg per 1 kg on the remaining days. In severe diseases, the stable dosage is 4 mg per 1 kg of body weight.

Application diagram for special cases:

1. With infectious tonsillitis, rheumatism and bilateral kidney damage by a pyogenic bacterium streptococcus pyogenes – 200 mg per day, course of treatment for at least 1.5 weeks.
2. In primary syphilis, the daily dosage is 200 mg, the course of therapy is 2 weeks. With the secondary appearance of the disease, it is necessary to conduct a monthly treatment course with the same dosage.
3. With severe acne lesions, the therapeutic course takes 1 – 2 months with a daily dose of 1 tablet.
4. For the prevention of tropical diseases, 100 mg is prescribed 3 days before departure for vacation. To protect against diarrhea, you should drink 200 mg of the medicine on the day of departure.
5. With a simple gonorrhea (gonorrhea), 600 mg of the drug is prescribed in two divided doses per day. The time interval between doses is 1 hour.

The maximum allowable dose for 1 day for a patient over 18 years of age – 600 mg. The therapeutic course at this dosage should not last longer than 5 days. The maximum allowable dose for a child – 4 mg per 1 kg.

How to use? The agent must be dissolved in 20 – 30 ml of purified warm water. The resulting suspension should be drunk. The drug should not be taken immediately before bedtime. It is advisable to drink it while eating, while in a sitting or standing position.

Unidox Solutab tablet must be dissolved in a glass of water

Contraindications and side effects

Unidox Solutab is strictly contraindicated:

• during pregnancy (the drug slows down the development of bones, negatively affects the formation of teeth in the fetus);
• during lactation (the active substance enters the mother's milk);
• with serious diseases of the kidneys and liver;
• with an increased level of porphyrins in the body;
• for children under eight years of age.

Also, the medication should not be taken by people with hypersensitivity to the components of the composition or tetracyclines. As side effects, allergic reactions may occur: swelling and rashes. If signs of intolerance appear, Unidox is replaced with another drug.

Common side effects:

• nausea and vomiting;
• diarrhea or constipation;
• papular rash;
• change in the shade of the teeth (in children);
• blurred vision, general weakness.

With prolonged therapy, anorexia, darkening of the thyroid tissue may occur. In patients with liver failure, severe lesions of this organ may appear.

When taking the drug, diarrhea may begin.

Drug compatibility

It is not recommended to take the medicine together with antacids at the same time. For the duration of treatment, it is better to abandon hormonal contraceptives, since Unidox reduces the reliability of this method of protection. With a one-time use with Retinol, the patient's intracranial pressure is significantly reduced.

With alcohol

Unidox and alcohol-containing drinks are incompatible with each other. Alcohol doubles the load on the liver, and the effect of the drug reduces to almost zero. The drug accelerates the absorption of the drink and increases the negative impact of alcoholic toxins. When combining the drug and alcohol, the following consequences may occur: hematemesis and diarrhea, fever, chills, dizziness.

In principle, alcohol should not be consumed during antibiotic therapy. Regardless of which medication the person is taking.
Do not take Unidox Solutab with alcohol

With dairy products

While taking antibiotics from the category of tetracyclines, it is strictly forbidden to consume any dairy products (regardless of the age and condition of the patient). Calcium contained in dairy foods reduces the effectiveness of the drug several times. After taking such products, the drug is not completely absorbed.

Antibiotics should also not be combined with carbonated drinks, natural juices and sour dishes (with the addition of vinegar).

During treatment with the drug, it is forbidden to eat any dairy products.

Doxycycline or Unidox Solutab – what's better?

The price of Unidox Solutab is 2.5 times higher than that of Doxycycline. Many people think that the differences between the drugs are insignificant, and choose a cheaper remedy. What actually causes the difference in the cost of medicines?

The Unidox formula allows it to quickly dissolve in water and be completely absorbed into the body. Along with this, the bioavailability of Doxycycline is only 50 – 60%. That is, the drug begins to act in the stomach, which is fraught with negative consequences - pain, spasms. With prolonged use, serious diseases of the digestive system may occur.

The second factor to be taken into account is – This is the effect of drugs on tooth enamel. Unidox can cause yellowing of teeth in children, as their enamel is several times weaker than in adults. After the use of Doxycycline, there is a change in the shade of the teeth in 30 – 40% of patients. Given these factors, Unidox still turns out to be better than Doxycycline, albeit more expensive.